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Saturday, July 29, 2006
Thursday, July 13, 2006
Where To Find MSDS On The Internet
Material Safety Data Sheets (MSDS) are an essential resource for those working with hazardous chemicals and include physical and chemical characteristics, hazards, safe handling, emergency and first aid procedures and more.
http://www.ilpi.com/msds/index.html offers on the one hand information on what MSDS actually is (with two examples) and on the other hand it contains information on where you can find MSDS, on the internet or elsewhere.
http://www.ilpi.com/msds/index.html offers on the one hand information on what MSDS actually is (with two examples) and on the other hand it contains information on where you can find MSDS, on the internet or elsewhere.
Sunday, July 24, 2005
12th International Conference on Boron Chemistry
September 11-15, 2005, Sendai, Japan
The 12th International Conference on Boron Chemistry (IMEBORON-XII) will be organized in September 11-15, 2005 at Sendai, Japan, under the sponsorship of IUPAC and COE program of Tohoku University. The organizing committee cordially invite you to participate in this meeting.
Topics
(1) Catalytic Reactions and Catalysts with Boron Compounds
(2) Cluster Chemistry of Boron and Boron Complexes
(3) Materials Using Boron
(4) Biological Activity of Boron and Supramolecular Chemistry of Boron
(5) Organic Synthesis with Boron, and Others
Source:hanyu.chem.tohoku.ac.jp/~web/IMEBORON/index.html
The 12th International Conference on Boron Chemistry (IMEBORON-XII) will be organized in September 11-15, 2005 at Sendai, Japan, under the sponsorship of IUPAC and COE program of Tohoku University. The organizing committee cordially invite you to participate in this meeting.
Topics
(1) Catalytic Reactions and Catalysts with Boron Compounds
(2) Cluster Chemistry of Boron and Boron Complexes
(3) Materials Using Boron
(4) Biological Activity of Boron and Supramolecular Chemistry of Boron
(5) Organic Synthesis with Boron, and Others
Source:hanyu.chem.tohoku.ac.jp/~web/IMEBORON/index.html
Monday, June 20, 2005
10th European Symposium on Organic Reactivity
The scientific focus of the ESOR 10 symposium will be organic reactivity, both in solution and in the gas phase. Particular emphasis will be given to the following topics: enzymatic and biomimetic catalysis, gas-phase reactions, supramolecular chemistry, transition metal catalysis, advanced materials, chemical modelling. Modern physical-organic chemistry, in fact, is not a circumscribed branch of chemistry, but rather a general strategy for the solution of chemical problems by physical methods and tools. It has the flexibility to deal with research problems in chemistry, physics, material science, molecular biology, molecular medicine and molecular dynamics.
Source:w3.uniroma1.it/esor_10/
Source:w3.uniroma1.it/esor_10/
Thursday, June 16, 2005
19th International Symposium : Synthesis in Organic Chemistry
The Organic Division of the RSC is pleased to announce the 19th International Symposium on Synthesis in Organic Chemistry, which will be held at St Catherine's College, Oxford, from Monday 18 July to Thursday 21 July 2005.
Participants will arrive on the afternoon and evening of Monday 18 July, and the conference sessions will begin on the morning of Tuesday 19 July.
The symposium is the latest in this biannual series, with meetings held alternately in Oxford and Cambridge, the first meeting having been held at Oxford in 1969. Synthesis in Organic Chemistry provides an international showcase for the core area of organic chemistry - synthesis. The symposium covers all aspects of contemporary organic synthesis and provides a forum for the ever more exciting methodologies and strategies that continue to emerge.
Participants will arrive on the afternoon and evening of Monday 18 July, and the conference sessions will begin on the morning of Tuesday 19 July.
The symposium is the latest in this biannual series, with meetings held alternately in Oxford and Cambridge, the first meeting having been held at Oxford in 1969. Synthesis in Organic Chemistry provides an international showcase for the core area of organic chemistry - synthesis. The symposium covers all aspects of contemporary organic synthesis and provides a forum for the ever more exciting methodologies and strategies that continue to emerge.
Tuesday, June 14, 2005
BioScience2005 - from genes to systems
BioScience2005 is the second Biochemical Society Annual Meeting and will comprise Symposia, Plenary Lectures, Medal Lectures, Oral Presentations and Poster Sessions. BioScience2005 will also provide a mix of Industrial Workshops, Policy Sessions, Education Workshops, Science and Society Sessions, Research Colloquia and Independent Scientific presentations.
Over 1500 research scientists from universities, research institutes and industry, working in biochemistry and molecular biology are expected to attend BioScience2005.
SECC, Glasgow is the UK's largest integrated exhibition and conference centre and the venue for a series of annual BioScience meetings. It is a world-class facility set in one of Europe's most vibrant cities. Glasgow's international airport is only a 15-minute drive from the SECC, providing direct access to and from major European and North American cities. Glasgow sits on the nationwide transport system with fast rail and road access to all the UK's principal cities.
Source:www.bioscience2005.org/
Source:www.bioscience2005.org/
Saturday, June 11, 2005
Screening Procedures
The ultimate goal of producing combinatorial libraries is to discover compounds that have some desired behavior and associated with this behavior some potential to serve as a drug. A major challenge in developing a library of compounds is screening the library for activity and identifying the chemical species responsible.
A reliable high-throughput assay is essential to successfully screen a combinatorial library.
The sets of compounds produced by combinatorial chemistry are generally referred to as libraries, which depending on how the solid-phase is handled, may be either mixtures or individual compounds. There are a range of options for testing the libraries in a biological assay:
1. Test mixture in solution: All the compounds are cleaved from the beads and tested in solution. If the resin beads were intimately mixed, it is not possible to test the products separately, but rather as a mixture. If activity in a pharmacological screen is observed it is not possible to say which compound or compounds are active. In order to identify the most active component, it is necessary to resynthesize the compounds individually and thereby find the most potent. This iterative process of resynthesis and screening is one of the most simple and successful methods for identifying active compounds from libraries.
2. Test individual compounds in solution: A second method is to separate the beads manually into individual wells and cleave the compounds from the solid-phase. These compounds can now be tested as individual entities.
3. Test compounds on the beads: A third method for screening is testing on the beads, using a colorimetric or fluorescent assay technique. If there are active compounds, the appropriate beads can be selected by color or fluorescence, ‘picked’ out by micromanipulation and the product structure, if a peptide, determined by sequencing on the bead. Non-peptide structures would need to be identified by one of the tagging methods. Screening on the bead may be an inappropriate method for drug discovery, as the bead and linker present conformational restrictions that may prevent binding to the receptor. Furthermore for pharmaceutical applications compounds will be invariably need to act, and thus ideally need to be tested in solution.
A reliable high-throughput assay is essential to successfully screen a combinatorial library.
The sets of compounds produced by combinatorial chemistry are generally referred to as libraries, which depending on how the solid-phase is handled, may be either mixtures or individual compounds. There are a range of options for testing the libraries in a biological assay:
1. Test mixture in solution: All the compounds are cleaved from the beads and tested in solution. If the resin beads were intimately mixed, it is not possible to test the products separately, but rather as a mixture. If activity in a pharmacological screen is observed it is not possible to say which compound or compounds are active. In order to identify the most active component, it is necessary to resynthesize the compounds individually and thereby find the most potent. This iterative process of resynthesis and screening is one of the most simple and successful methods for identifying active compounds from libraries.
2. Test individual compounds in solution: A second method is to separate the beads manually into individual wells and cleave the compounds from the solid-phase. These compounds can now be tested as individual entities.
3. Test compounds on the beads: A third method for screening is testing on the beads, using a colorimetric or fluorescent assay technique. If there are active compounds, the appropriate beads can be selected by color or fluorescence, ‘picked’ out by micromanipulation and the product structure, if a peptide, determined by sequencing on the bead. Non-peptide structures would need to be identified by one of the tagging methods. Screening on the bead may be an inappropriate method for drug discovery, as the bead and linker present conformational restrictions that may prevent binding to the receptor. Furthermore for pharmaceutical applications compounds will be invariably need to act, and thus ideally need to be tested in solution.
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